CrossTalk proposal: 5-HT is necessary for peristalsis
نویسندگان
چکیده
منابع مشابه
CrossTalk proposal: 5-HT is necessary for peristalsis.
The overwhelming preponderance of the 5-HT of every known mammal is in the gut (Erspamer, 1966; Gershon & Tack, 2007; Gershon, 2013). Enteric 5-HT must be an important signalling molecule to be so conserved. Most enteric 5-HT is in enterochromaffin (EC) cells, but smaller amounts are present in myenteric neurons. Despite their small numbers, serotonergic neurons project widely throughout the en...
متن کاملCrossTalk opposing view: 5-HT is not necessary for peristalsis.
Large quantities of 5-hydroxytryptamine (5-HT) are synthesized in the gut, in enterochromaffin (EC) cells of the mucosa (via tryptophan hydroxylase-1) and in a small proportion in enteric neurons (via tryptophan hydroxylase-2). It has been well established that 5-HT can be released from the mucosa by mechanical stimulation, including contractile activity of the gut and compression of the gut wa...
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Antagonists of 5-Hydroxytryptamine (5-HT) receptors are well known to inhibit gastrointestinal (GI)-motility and transit in a variety of mammals, including humans. Originally, these observations had been interpreted by many investigators (including us) as evidence that endogenous 5-HT plays a major role in GI motility. This seemed a logical assumption. However, the story changed dramatically af...
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Hypercapnia-induced arousal from sleep is an important protective mechanism pertinent to a number of diseases. Most notably among these are the sudden infant death syndrome, obstructive sleep apnea and sudden unexpected death in epilepsy. Serotonin (5-HT) plays a significant role in hypercapnia-induced arousal. The mechanism of 5-HT's role in this protective response is unknown. Here we sought ...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2015
ISSN: 0022-3751
DOI: 10.1113/jp270182